Studies
Cord blood derived cell therapies
Autologous cells
CORD-Safe (Safety and feasibility study in extremely preterm infants) - completed - publications:
STELLAR (Feasibility and safety study of multiple infusions in infants with antenatally diagnosed fetal stroke) - ongoing
CORD-CELL (International Randomised controlled trial testing efficacy of autologous cells in extremely preterm infants) - ongoing
Allogeneic cells
ALLO trial (Feasibility and safety of allogeneic partially matched cells in preterm infants with severe preterm brain injury) - ongoing - publications:
Expanded CD34+ cells
Pre-clinical studies* (in vitro and in vivo studies) - ongoing - publications:
Amnion derived cells
Stem cell BPD study (Safety and feasibility study in infants with established bronchopulmonary dysplasia) - completed - publications:
RENEWAL (Dose escalation study in preterm infants at high risk of bronchopulmonary dysplasia) - completed - publications:
Exosomes/ Extracellular vesicles
Amnion derived EVs
Pre-clinical studies ongoing (in vitro and in vivo studies)
Neural stem cells
Pre-clinical studies ongoing (in vitro and in vivo studies)
Selected Other Publications
Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury: A Systematic Review & Meta-Analysis of Preclinical Studies.
Nguyen T, Purcell E, Smith MJ, Penny TR, Paton MCB, Zhou L, Jenkin G, Miller SL, McDonald CA, Malhotra A. Int J Mol Sci. 2023 Feb 22;24(5):4351. doi: 10.3390/ijms24054351. PMID: 36901781 Free PMC article. Review.
Factors Influencing the Efficacy of Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury.
Purcell E, Nguyen T, Smith M, Penny T, Paton MCB, Zhou L, Jenkin G, Miller SL, McDonald CA, Malhotra A. Stem Cells Transl Med. 2023 Mar 17;12(3):125-139. doi: 10.1093/stcltm/szad006. PMID: 36847059 Free PMC article.Endothelial colony forming cell administration promotes neurovascular unit development in growth restricted and appropriately grown fetal lambs.
Bell A, Watt AP, Dudink I, Pham Y, Sutherland AE, Allison BJ, McDonald CA, Castillo-Melendez M, Jenkin G, Malhotra A, Miller SL, Yawno T.Stem Cell Res Ther. 2023 Feb 14;14(1):29. doi: 10.1186/s13287-023-03249-z. PMID: 36788590 Free PMC article.Feasibility of cord blood collection for autologous cell therapy applications in extremely preterm infants.
Zhou L, McDonald CA, Yawno T, Penny T, Miller SL, Jenkin G, Malhotra A. Cytotherapy. 2023 Feb 3:S1465-3249(23)00007-5. doi: 10.1016/j.jcyt.2023.01.001. Online ahead of print. PMID: 36740465Acceptability of neural stem cell therapy for cerebral palsy: survey of the Australian cerebral palsy community.
Smith MJ, Finch-Edmondson M, Miller SL, Webb A, Fahey MC, Jenkin G, Paton MCB, McDonald CA. Stem Cell Res Ther. 2023 Feb 3;14(1):18. doi: 10.1186/s13287-023-03246-2. PMID: 36737828 Free PMC article.Umbilical Cord Blood and Cord Tissue-Derived Cell Therapies for Neonatal Morbidities: Current Status and Future Challenges.
Zhou L, McDonald C, Yawno T, Jenkin G, Miller S, Malhotra A. Stem Cells Transl Med. 2022 Mar 17;11(2):135-145. doi: 10.1093/stcltm/szab024. PMID: 35259278 Free PMC article.Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function.
Watt AP, Kirkland M, Nekkanti L, Pham Y, McDonald C, Malhotra A, Moeneclaey G, Miller SL, Jenkin G. Cell Tissue Res. 2022 Apr;388(1):117-132. doi: 10.1007/s00441-022-03592-2. Epub 2022 Feb 2. PMID: 35106623 Free PMC article.Neural stem cell treatment for perinatal brain injury: A systematic review and meta-analysis of preclinical studies.
Smith MJ, Paton MCB, Fahey MC, Jenkin G, Miller SL, Finch-Edmondson M, McDonald CA. Stem Cells Transl Med. 2021 Dec;10(12):1621-1636. doi: 10.1002/sctm.21-0243. Epub 2021 Sep 20. PMID: 34542242 Free PMC article.Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males.
Penny TR, Pham Y, Sutherland AE, Lee J, Jenkin G, Fahey MC, Miller SL, McDonald CA. Sci Rep. 2021 Aug 4;11(1):15788. doi: 10.1038/s41598-021-95035-1. PMID: 34349144 Free PMC article.Window of opportunity for human amnion epithelial stem cells to attenuate astrogliosis after umbilical cord occlusion in preterm fetal sheep.
Davidson JO, van den Heuij LG, Fraser M, Wassink G, Miller SL, Lim R, Wallace EM, Jenkin G, Gunn AJ, Bennet L. Stem Cells Transl Med. 2021 Mar;10(3):427-440. doi: 10.1002/sctm.20-0314. Epub 2020 Oct 26. PMID: 33103374 Free PMC article.Multiple doses of umbilical cord blood cells improve long-term brain injury in the neonatal rat.
Penny TR, Pham Y, Sutherland AE, Mihelakis JG, Lee J, Jenkin G, Fahey MC, Miller SL, McDonald CA. Brain Res. 2020 Nov 1;1746:147001. doi: 10.1016/j.brainres.2020.147001. Epub 2020 Jul 2. PMID: 32585139Autologous transplantation of umbilical cord blood-derived cells in extreme preterm infants: protocol for a safety and feasibility study.
Malhotra A, Novak I, Miller SL, Jenkin G. BMJ Open. 2020 May 11;10(5):e036065. doi: 10.1136/bmjopen-2019-036065. PMID: 32398336 Free PMC article.Is Umbilical Cord Blood Therapy an Effective Treatment for Early Lung Injury in Growth Restriction?
Allison BJ, Youn H, Malhotra A, McDonald CA, Castillo-Melendez M, Pham Y, Sutherland AE, Jenkin G, Polglase GR, Miller SL. Front Endocrinol (Lausanne). 2020 Mar 3;11:86. doi: 10.3389/fendo.2020.00086. eCollection 2020. PMID: 32194502 Free PMC article.Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs : UCBCs for perinatal brain injury.
Malhotra A, Castillo-Melendez M, Allison BJ, Sutherland AE, Nitsos I, Pham Y, McDonald CA, Fahey MC, Polglase GR, Jenkin G, Miller SL. Stem Cell Res Ther. 2020 Jan 8;11(1):17. doi: 10.1186/s13287-019-1526-0. PMID: 31915068 Free PMC article.Intranasal Delivery of Mesenchymal Stromal Cells Protects against Neonatal Hypoxic⁻Ischemic Brain Injury.
McDonald CA, Djuliannisaa Z, Petraki M, Paton MCB, Penny TR, Sutherland AE, Castillo-Melendez M, Novak I, Jenkin G, Fahey MC, Miller SL. Int J Mol Sci. 2019 May 17;20(10):2449. doi: 10.3390/ijms20102449. PMID: 31108944 Free PMC article.Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury.
Penny TR, Sutherland AE, Mihelakis JG, Paton MCB, Pham Y, Lee J, Jones NM, Jenkin G, Fahey MC, Miller SL, McDonald CA. Front Physiol. 2019 Mar 22;10:283. doi: 10.3389/fphys.2019.00283. eCollection 2019. PMID: 30967791 Free PMC article.Umbilical cord blood versus mesenchymal stem cells for inflammation-induced preterm brain injury in fetal sheep.
Paton MCB, Allison BJ, Fahey MC, Li J, Sutherland AE, Pham Y, Nitsos I, Bischof RJ, Moss TJ, Polglase GR, Jenkin G, Miller SL, McDonald CA. Pediatr Res. 2019 Aug;86(2):165-173. doi: 10.1038/s41390-019-0366-z. Epub 2019 Mar 11. PMID: 30858474Human Umbilical Cord Blood Therapy Protects Cerebral White Matter from Systemic LPS Exposure in Preterm Fetal Sheep.
Paton MCB, Allison BJ, Li J, Fahey MC, Sutherland AE, Nitsos I, Bischof RJ, Dean JM, Moss TJM, Polglase GR, Jenkin G, McDonald CA, Miller SL. Dev Neurosci. 2018;40(3):258-270. doi: 10.1159/000490943. Epub 2018 Sep 4. PMID: 30179864Preterm umbilical cord blood derived mesenchymal stem/stromal cells protect preterm white matter brain development against hypoxia-ischemia.
Li J, Yawno T, Sutherland AE, Gurung S, Paton M, McDonald C, Tiwari A, Pham Y, Castillo-Melendez M, Jenkin G, Miller SL. Exp Neurol. 2018 Oct;308:120-131. doi: 10.1016/j.expneurol.2018.07.006. Epub 2018 Jul 20. PMID: 30012511Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury.
McDonald CA, Penny TR, Paton MCB, Sutherland AE, Nekkanti L, Yawno T, Castillo-Melendez M, Fahey MC, Jones NM, Jenkin G, Miller SL. J Neuroinflammation. 2018 Feb 17;15(1):47. doi: 10.1186/s12974-018-1089-5. PMID: 29454374 Free PMC article.Umbilical cord blood cells for treatment of cerebral palsy; timing and treatment options.
McDonald CA, Fahey MC, Jenkin G, Miller SL. Pediatr Res. 2018 Jan;83(1-2):333-344. doi: 10.1038/pr.2017.236. Epub 2017 Nov 1. PMID: 28937975 Review.Term vs. preterm cord blood cells for the prevention of preterm brain injury.
Li J, Yawno T, Sutherland A, Loose J, Nitsos I, Allison BJ, Bischof R, McDonald CA, Jenkin G, Miller SL. Pediatr Res. 2017 Dec;82(6):1030-1038. doi: 10.1038/pr.2017.170. Epub 2017 Aug 16. PMID: 28723885Preterm white matter brain injury is prevented by early administration of umbilical cord blood cells.
Li J, Yawno T, Sutherland A, Loose J, Nitsos I, Bischof R, Castillo-Melendez M, McDonald CA, Wong FY, Jenkin G, Miller SL. Exp Neurol. 2016 Sep;283(Pt A):179-87. doi: 10.1016/j.expneurol.2016.06.017. Epub 2016 Jun 16. PMID: 27317990Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb.
Aridas JD, McDonald CA, Paton MC, Yawno T, Sutherland AE, Nitsos I, Pham Y, Ditchfield M, Fahey MC, Wong F, Malhotra A, Castillo-Melendez M, Bhakoo K, Wallace EM, Jenkin G, Miller SL. J Physiol. 2016 Mar 1;594(5):1421-35. doi: 10.1113/JP271104. Epub 2015 Dec 14. PMID: 26527561 Free PMC article.